201170
Sigma-Aldrich

PHOSPHORUS (V) OXYCHLORID E, REAGENTPLUS,

Linear Formula:

POCl3

Empform:

Cl3OP

Synonyms English:

Phosphorus(V) oxide chloride

Nacres: NA.22
Mdl No: MFCD00011443
Fw: 153.33
Pubchem Substance Id: 57647818
CAS Number: 10025-87-3
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Properties

Properties
assay 99%
bp 105.8 
bromine number ?C (lit.)
density of sugar measuring range 1.645 
depth g/mL 
depth × h × w at 25 
depth × overall h ?C (lit.)
Description PHOSPHORUS (V) OXYCHLORID E, REAGENTPLUS,
frame size liquid
inlet and outlet diam. 1S/Cl3OP/c1-5(23)4
inlet and outlet nptm × nptm XHXFXVLFKHQFAL-UHFFFAOYSA-N
Import License Temp. Regu
Check Obsolete No
Temperature Control 1554
Shipping Mode DS
Business Unit Chemistry

Description

Application

Phosphorus(V) oxychloride (POCl3) is a chlorinating agent that reacts with dimethylformamide (DMF) to form Vilsmeier reagent for Vilsmeier-Haack formylation reactions.
It can also be used as a reagent in the synthesis of:
  • Quinazolin-4(3H)-one derivatives from 2-aminobenzamides via in situ preparation of Vilsmeier reagent.
  • Substituted 1-arylseleno-4-halo-2-enes by treating conjugated dienes with arylselenenamides.
  • 3-methylthioimidazo[1,2-a]pyridines and imidazo-fused heterocycles in the presence of DMSO.

SAFETY INFORMATION

GHS05,GHS06,GHS08

Signal Word

Danger

H302 - H314 - H330 - H372

P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P314

RIDADRRIDADR

WGK Germany

WGK 1

Flash Point (F)

Not applicable

Flash Point (C)

Not applicable

Target Organs

Risk Statement

Supplemental Hazard Statements

DOCUMENTATION

Certificate of Analysis View Sample COA
Certificate of Origin

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