I 2000 RSP chiral HPLC column is basically comprised of native and derivatized β
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cyclodextrins. It has been used for numerous chiral separations via selectively trapping the organic molecules in the cyclodextrin cavity.
The hydroxyl groups on the surface of the β-cyclodextrin are reacted with (R,S)-propylene oxide to yield a general purpose chiral stationary phase. It has the added property of separating non-aromatic structures such as t-boc amino acids, for which it is a standard methodology.