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239763-M

Cycloheximide

CAS Number: 66-81-9
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Properties

Properties
Description Cycloheximide
Import License Not required
Check Obsolete 12/31/9999 12:00:00 AM
Temperature Control 45
Business Unit P98

Description

General description

Cycloheximide is an antibiotic having significant antifungal properties. It is produced by streptomycin-producing strains of Streptomyces griseus and acts by inhibiting protein synthesis. Its main biological activity is translation inhibition in eukaryotes resulting in cell growth arrest and cell death. It is used as a fungicide. As per Regulation (EC) No 1107/2009, repealing the directive 91/414, cycloheximide is not approved for use in the European Union (EU).

Application

Cycloheximide may find the following uses: To evaluate the antifungal efficacy and safety of cycloheximide as a supplement in Optisol-GS To study the effect of cycloheximide on leaf-cutting ant workers To study the effect of streptomycin, cycloheximide, fungizone, captan, carbofuran, cygon, and pentachloronitrobenzene on soil microorganisms To study the fungal control of nitrous oxide production in a semiarid grassland To study the activity and degradation of streptomycin and cycloheximide in soil

Biochem/physiol Actions

Cycloheximide (CHX) is an antibiotic produced by S. griseus. Its main biological activity is translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors.

Legal Information

PESTANAL is a registered trademark of Sigma-Aldrich International GmbH

Warning

Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I)

SAFETY INFORMATION

GHS06,GHS08,GHS09

Signal Word

Danger

H300 - H341 - H360D - H411

P201 - P202 - P264 - P270 - P273 - P301 + P310

RIDADRRIDADR

WGK Germany

WGK 3

Flash Point (F)

Not applicable

Flash Point (C)

Not applicable

Target Organs

Risk Statement

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

Supplemental Hazard Statements

DOCUMENTATION

Certificate of Analysis View Sample COA
Certificate of Origin

TECHNICAL SERVICE

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