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E0774
Sigma-Aldrich

Erythromycin, meets USP testing specific

Empform:

C37H67NO13

Nacres: NA.76
Mdl No: MFCD00084654
Fw: 733.93
Pubchem Substance Id: 24894374
CAS Number: 114-07-8
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Thuộc tính

Thuộc tính
agency USP/NF
antibiotic activity spectrum Gram-negative bacteria
applications pharmaceutical (small molecule)
form solid
gene information human ... ABCB1(5243) CYP3A4(1576) MLNR(2862)
mouse ... Abcb1a(18671) Abcb1b(18669)
inchi 1S/C37H67NO13/c1-14-25-37(1045)30(41)20(4)27(39)18(2)16-35(844)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(946-13)31(42)23(7)48-26/h18-2628-323440-4244-45H14-17H21-13H3/t18-19-20+21+22-23+24+25-26+28-29+30-31+32-34+35-36-37-/m1/s1
inchi key ULGZDMOVFRHVEP-RWJQBGPGSA-N
Yêu cầu giấy phép Not required
Kiểm tra hết hạn No
Kiểm soát nhiệt độ 1554
Hình thức vận chuyển DAS
Lĩnh vực sản phẩm Chemistry

Mô tả

Application

Erythromycin is an antibiotic produced by growth of certain strains of Streptomyces erythreus. This product is composed largely of erythromycin A with small amounts of erythromycins B and C and is recommended for concentration at 100 mg/L. Concentrations between 50 and 200 mg/L have also proven effective in controlling bacterial growth. Erythromycin has been used as a motilin receptor agonist, to block respiratory glycoconjugate secretion in human airways in vitro, and for selecting plasmid-cured and recombinant lactococcus lactis MG1363 strains.

Biochem/physiol Actions

Mode of Action: Erythromycin acts by inhibiting elongation at the transpeptidation step, specifically aminoacyl translocation from the A-site to P-site by binding to the 50s subunit of the bacterial 70s rRNA complex.

Antimicrobial Spectrum: This product acts against both gram-negative and gram-positive bacteria.

Caution

This product is stable in solution at 37°C for 3 days. Stock solutions should be stored at 2-8°C.

General description

Chemical structure: macrolide

Preparation Note

This product is soluble in water at 2 mg/mL, with a 0.067% solution in water yielding a pH of 8.0-10.5. It is also soluble in ethanol at 50 mg/mL, yielding a clear, colorless to faint yellow solution. It is freely soluble in alcohol, acetone, chloroform, acetonitrile and ethyl acetate but forms salts with acids. All solutions should be protected from light.

THÔNG TIN AN TOÀN

Signal Word

RIDADRRIDADR

WGK Germany

WGK 3

Flash Point (F)

Not applicable

Flash Point (C)

Not applicable

Target Organs

Risk Statement

Cảnh cáo nguy cơ bổ sung

TÀI LIỆU

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